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Biochem Cell Arch 20:27272733 Alsadee SAA (2021) Hepato-nephroprotective role of Lepidium sativum against oxidative stress induced by dexamethasone in rats

Worth mentioning, as Selyes stress concept (Selyes stress response against various noxious agents to reestablish homeostasis) [31,32] gave birth years later to Roberts cytoprotection concept [16,17] (for review see, i.e., [33]), the cytoprotection concept holds a response that is specifically related to prevent or recover damage as such

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259 Furthermore, endotoxin dose-dependent switch of NAD + biosynthesis pathways from NAMPT-dependent salvage to IDO1-dependent de novo biosynthesis maintains the nuclear NAD + pool, which promotes SIRT1-directed epigenetic regulation of immune tolerance